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Immature granulocytes are precursors to neutrophils, which play a pivotal role in the immune system. These cells originate in the bone marrow and are used as markers for many physiological conditions. (source)
Generally, low levels of immature granulocytes are considered a marker of good health in adults.
Low levels of immature granulocytes usually do not require specific treatment unless they are associated with a specific illness. There is no suggested nutritional, lifestyle, or supplement-based intervention.
Elevated immature granulocytes may result from physiological responses to stress or infection, as the bone marrow increases the production of these cells to combat perceived threats to the body. From a nutritional perspective, deficiencies in vitamin B12 and other key nutrients can impair the maturation process of granulocytes in the bone marrow. (source, source)
Prioritize vitamin C-rich foods: Vitamin C has been shown to have anti-inflammatory properties, helping to lower immature granulocyte levels. (source) Vitamin C is a cofactor for enzymes involved in the differentiation process of hematopoietic stem cells, essentially promoting their maturation into functional granulocytes. Additionally, it aids in the regulation of new blood cell production, thereby reducing immature granulocytes in the bloodstream. (source) Recommendation: Consume at least one serving of foods high in vitamin C, daily.
One serving examples: Red Bell Peppers (chopped) (1 cup), Strawberries (8 medium strawberries), Orange (1 medium orange), Grapefruit (½ large grapefruit), Citrus Juice (100%) (½ cup)
Avoid smoking: Smoking has been shown to negatively affect bone marrow physiology leading to negative effects in granulocyte development, resulting in increased blood levels. (source) Smoking causes chronic inflammation that contributes to chronic stimulation of bone marrow, leading to the premature release of white blood cells, including band cells (an indicator of immature granulocytes), into the bloodstream. (source) Recommendation: If a smoker, take the steps to quit. If not, avoid areas where secondhand smoke is present.
Supplement with vitamin C: Vitamin C has been shown to have anti-inflammatory properties, helping to lower immature granulocyte levels. (source) Vitamin C is a cofactor for enzymes involved in the differentiation process of hematopoietic stem cells, essentially promoting their maturation into functional granulocytes. Additionally, it aids in the regulation of new blood cell production, thereby reducing immature granulocytes in the bloodstream. (source) Recommendation: Supplement with at least 100 mg of vitamin C daily.
