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Biomarkers

Omega-6, Total

Why It Matters

Omega-6 fatty acids are polyunsaturated fatty acids that are found throughout the body, and they help with cellular function. Omega-6 fatty acids are not synthesized by the body and must be obtained through diet. (source, source)

Low Omega-6, Total: Insufficient Omega-6 Status

Low total omega-6 stems from physiological factors impacting the body's ability to convert precursor fatty acids into omega-6 fatty acids. Nutritionally, a diet deficient in sources of omega-6 fatty acids, such as certain plant oils and nuts, contributes to lower levels. (source, source)

Potential Performance Impact:

  • Insufficient omega-6 status compromises cell membrane structure and function across multiple tissues
  • Low omega-6 levels impair the acute inflammatory response needed for tissue repair after training
  • Reduced omega-6 availability limits energy substrate for sustained efforts
  • Suboptimal levels disrupt immune cell signaling, increasing susceptibility to illness during heavy training

Optimization

Prioritize foods with omega-6 fatty acids: Ingestion of omega-6 fatty acids has been shown to increase omega-6 fatty acid levels. (source)

Protocol: Consume one serving of foods with omega-6 fatty acids daily. One serving examples: Sunflower Seeds (1 oz), Walnuts (1 oz), Mayonnaise (1 tbs).

Supplement with linoleic acid: Ingestion of omega-6 fatty acids has been shown to increase omega-6 fatty acid levels in the body. (source)

Protocol: Supplement with 4 g of safflower oil.

High Omega-6, Total: Excess Omega-6 Accumulation

Omega-6 fatty acids are primarily derived from the diet. A diet disproportionately high in omega-6 fatty acids compared to omega-3s contributes to elevated levels. (source, source)

Potential Performance Impact:

  • Excess omega-6 drives chronic pro-inflammatory signaling that impairs recovery and adaptation
  • Elevated omega-6 relative to omega-3 shifts eicosanoid balance toward inflammation
  • Surplus omega-6 competes with omega-3 for enzymatic conversion, blunting anti-inflammatory pathways
  • Chronic omega-6 excess promotes systemic inflammation that reduces training tolerance

Optimization

Limit foods high in omega-6 fatty acids: Ingestion of omega-6 fatty acids has been shown to increase omega-6 fatty acid levels in the body. (source) Limiting intake of foods high in omega-6 fatty acids decreases total omega-6.

Protocol: Monitor and limit excess consumption of foods high in omega-6 fatty acids, like walnuts and eggs.